Chief Dennis Guidry and the Jefferson Parish fire department responded to the scene on across the street from the Eastbank Regional library off West Napoleon around 3:00am.
"We have a two alarm structure fire in the 2300 block of Harvard Avenue with three victims that have perished as a result of the fire," the chief said at the scene. "There's one individual who was transported to the hospital after escaping through a window."
That person has leg injuries after jumping from the top floor.
The three people who died were all in the same apartment. Several other people were displaced by the blaze. The cause is under investigation.