Police say one person died in the crash involving a tour bus and a car.
New Orleans EMS spokesman Jeb Tate says a person died in the car.
"Luckily there were very few injuries in the tour bus," he explained. "Our paramedics transported four people from the tour bus, all with very minor injuries."
The bus was bringing elementary school kids from Florida to New Orleans.
This witness saw the car spin out of control and cross the median into oncoming traffic.
"I noticed there was a car spinning out of control heading eastbound," he described. "As I passed, that vehicle wound up in the left lane westbound."
The car then collided with the bus.
The witness says it was raining at the time.