Andrew Kreig head of The Justice Project, says the resignation underscores what he calls endemic problems in U.S. prosecutors' offices across the country.
"We know that we cannot trust the government, and finally you have the full admission that you cannot," Kreig said.
Kreig says the ongoing scandal in Letten's office led to a breakdown of confidence in an office that many believed to be above the fray.
"I've had people come up to me since all this broke and said, "you know, I kind of trust what the government is telling me (if I am on a jury,) if I'm really supposed to believe that these people are guilty of crimes they are accused of."
Kreig agrees with a New Orleans federal judge that an independent investigator should be brought in to look into the alleged misconduct by two top prosecutors in Letten's office.
"Specifically, people have said, well, isn't this "misprion of a felony" if Mann didn't say anything when Letten was telling a judge that no one else was doing this," according to Kreig. "Did Perricone perjure himself when he was talking to the judge under oath from court? This really kinds of screws up the federal judicial system in the Eastern District. It's a sad day, it really is."